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Cancer drugs affect mouse genomes for generations: DNA mutations continue to accumulate in offspring of treated mice. Three common chemotherapy drugs cause DNA mutations not only in mice that receive treatment, but also in their offspring, according to a study published today in the Proceedings of the National Academy of Sciences USA1.
The results suggest that the genome in treated mice became destabilized yielding new mutations long after exposure to the drugs has ceased. A similar phenomenon has been observed in mice exposed to radiation.
Genomic damage can be seen in the offspring of mice who have received chemotherapy drugs. (Nature)
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